I use a Generic form of Roundup...I buy it from a local farm store for a fraction of the cost of buying the Brand name at the stores. I use it on my long gravel driveway a couple of times per year to keep the driveway from turning into a weed bed. However, when I get ready to "spray", I make sure the wind is calm, and I mix it carefully into the sprayer, and even wear a "painters" mask so as to not breathe in any of the fumes. Like anything else, if a person uses common sense, and follows the instructions, the risks are minimal.